What is the medicine diclofenac sodium used for
Diclofenac, sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. It is taken by mouth, rectally in a suppository, used by injection, or applied to the skin. Improvements in pain last for as much as eight hours. It is also available in combination with misoprostol in an effort to decrease. Diclofenac Sodium is the sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac sodium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors.
Medically reviewed by Kaci Durbin, MD. Last updated on Dec 1, This medicine works by reducing substances in the body that cause pain and inflammation.
Diclofenac is used to treat mild to moderate pain, or signs and symptoms how to study well for an exam osteoarthritis or rheumatoid arthritis. Voltaren is also indicated for the treatment of ankylosing spondylitis.
The Cataflam brand of this medicine is also used to treat menstrual cramps. Diclofenac powder Cambia is used to treat a migraine headache attack. Cambia will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. You should not use diclofenac if you have a history of allergic reaction to aspirin or NSAIDs non-steroidal anti-inflammatory how to switch from sim to micro sim. Diclofenac can increase your risk of fatal heart attack or strokeespecially if you use it long term or take high doses, or if you have heart disease.
Do not use this medicine just before or after heart usee surgery coronary artery bypass graft, or CABG. Diclofenac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults. Diclofenac can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. You should not use diclofenac if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.
Do not use Cambia to treat a cluster headache. Usde not use Zipsor if you are allergic to beef or beef protein. Diclofenac can affect ovulation and it may be harder to get thf while you are using this medicine. If you are pregnant, you should not msdicine diclofenac unless your doctor tells you to.
Taking a NSAID medicibe the last 20 weeks of pregnancy can what is drag in physics serious js or kidney how to locate a mobile phone number in the unborn baby and possible complications with your pregnancy. Take diclofenac exactly as prescribed whhat your doctor. Follow the directions on your prescription label and read all medication guides.
Your doctor diclifenac occasionally change your dose. Use the lowest dose that is effective in treating your condition. Different brands of diclofenac contain different amounts of diclofenac, and may have different uses. If you switch brands, your dose needs may change. Follow your doctor's instructions about how much medicine to take. Ask your pharmacist if you medicins any questions about nedicine brand you receive at the pharmacy. Dissolve the powder form of this medicine Cambia with 1 to 2 ounces of water.
Do not use any other type of liquid. Stir this mixture and drink all of it right away. Cambia works best if you take it whzt an empty stomach. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Diclofenac flr acid capsules: 35 mg orally 3 times a day Diclofenac potassium immediate-release tablets: 50 mg orally 2 or 3 times a day Diclofenac sodium enteric-coated tablets: 50 mg orally 2 or 3 times a day or 75 mg orally 2 times a day Maximum dose: mg daily Diclofenac sodium extended-release tablets: mg orally once a day Use: For the relief of signs and symptoms of osteoarthritis.
Diclofenac sodium enteric-coated and delayed-release tablets: 25 mg orally 4 times a day. An additional 25 mg dose may be uaed at bedtime, if necessary Maximum dose: mg per day Use: For acute or what to get a male high school graduate use in the relief of signs and symptoms of ankylosing spondylitis. Diclofenac potassium immediate-release tablets: 50 mg orally 3 times a day Comments: An initial dose of mg orally followed by 50 mg oral doses may provide better relief for some patients; initiate treatment upon appearance of the first symptoms and continue for a few days.
Use: For the relief of signs and symptoms of primary dysmenorrhea. Diclofenac potassium immediate-release tablets: 50 mg orally 3 or 4 times a day Diclofenac sodium enteric-coated and delayed-release tablets: 50 mg orally 3 to medicije times usrd day or 75 mg orally twice a day Maximum dose: mg daily Diclofenac sodium extended-release tablets: mg orally once a day Maximum dose: mg orally 2 times a day; this would be for the rare patient in whom the benefits outweigh the clinical risks.
For the relief of signs and symptoms of rheumatoid arthritis. Diclofenac potassium for oral solution packets: 50 mg 1 packet orally once Comments: This drug is not indicated for the prophylactic what is the manoeuvre warfare of migraine or for medicinf in cluster headaches; the safety and efficacy of a second dose has not been established. Use: For acute treatment of migraine with or without aura. Oral: Diclofenac potassium liquid-filled capsules: 25 mg orally 4 times diclofenwc day Diclofenac free acid capsules: 18 mg or 35 mg orally 3 times a day Diclofenac potassium immediate-release tablets: 50 mg orally 3 times a day; an initial dose of mg orally followed by 50 mg oral doses may provide better relief in some patients.
Parenteral: How to unthaw frozen chicken For the management of mild to moderate acute pain oral, IV and moderate to severe pain alone or in combination with opioid analgesics IV.
Take the missed diclfoenac as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. They may contain ingredients similar to diclofenac such as aspirin, ibuprofen medickne, ketoprofenor naproxen. Get emergency medical help if you have signs of an allergic reaction to diclofenac hivesdifficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throatburning eyes, skin pain, red or purple skin rash with blistering and peeling.
Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath. This is not a complete list of side effects and others ie occur. Call your doctor for medical advice about side effects.
Ask your doctor before using diclofenac if you take an antidepressant. This list is not complete. Other drugs may interact with diclofenac, including prescription and over-the-counter medicines, vitaminsand diclofenca products. Not all possible drug interactions are listed here. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use dicloffenac only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to medicime personal circumstances. Detailed Diclofenac dosage information. Diclofenac side effects more detail. Diclofenac drug interactions more detail. Drug Whst Availability Prescription only Rx. Lannett Company, Inc. Mylan Pharmaceuticals Inc. Sandoz Inc. Drug Class. Nonsteroidal anti-inflammatory drugs.
1. About diclofenac
Jan 01, · Diclofenac Sodium Topical Solution contains % w/w diclofenac sodium, a benzeneacetic acid derivative that is a nonsteroidal anti-inflammatory drug (NSAID), designated chemically as 2-[(2,6dichlorophenyl)amino]-benzeneacetic acid, monosodium salt. Dec 01, · Diclofenac is used to treat mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis. Voltaren is also indicated for the treatment of ankylosing spondylitis. The Cataflam brand of this medicine is also used to treat menstrual cramps. Diclofenac powder (Cambia) is used to treat a migraine headache attack. Cambia. Mar 25, · The name of your medicine is Diclofenac Sodium 50mg. Diclofenac Sodium 50mg: Each gastro-resistant tablet contains 50 mg of the active ingredient diclofenac sodium, and also contains the following inactive ingredients: tablet core: copolyvidone, microcrystalline cellulose, colloidal anhydrous silica.
Diclofenac , sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug NSAID used to treat pain and inflammatory diseases such as gout. Common side effects include abdominal pain , gastrointestinal bleeding , nausea, dizziness, headache, and swelling. Diclofenac was patented in by Ciba-Geigy ; it came into medical use in the United States in Diclofenac is used to treat pain , inflammatory disorders , and dysmenorrhea.
Inflammatory disorders may include musculoskeletal complaints [ clarification needed ] , especially arthritis , rheumatoid arthritis , polymyositis , dermatomyositis , osteoarthritis , dental pain , temporomandibular joint TMJ pain, spondylarthritis , ankylosing spondylitis , gout attacks,  and pain management in cases of kidney stones and gallstones.
An additional indication is the treatment of acute migraines. Diclofenac is also available in topical forms and has been found to be useful for osteoarthritis but not other types of long-term musculoskeletal pain. It may also help with actinic keratosis , and acute pain caused by minor strains, sprains, and contusions bruises.
In many countries,  eye drops are sold to treat acute and chronic nonbacterial inflammation of the anterior part of the eyes e. Diclofenac eye drops have also been used to manage pain for traumatic corneal abrasion. Diclofenac is often used to treat chronic pain associated with cancer , especially if inflammation is present.
Voltaren diclofenac 50 mg enteric coated tablets. Arthrotec diclofenac and misoprostol 50 mg tablets. Dyloject diclofenac 2 ml for IV and IM administration. Sintofarm diclofenac for suppository administration. Diclofenac consumption has been associated with significantly increased vascular and coronary risk in a study including coxib, diclofenac, ibuprofen and naproxen. In October , the U. Food and Drug Administration FDA required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.
In , a study found major vascular events were increased by about a third by diclofenac, chiefly due to an increase in major coronary events.
Following the identification of increased risks of heart attacks with the selective COX-2 inhibitor rofecoxib in , attention has focused on all the other members of the NSAIDs group, including diclofenac.
Research results are mixed, with a meta-analysis of papers and reports up to April suggesting a relative increased rate of heart disease of 1. Only aspirin was found not to increase the risk of heart disease; however, this is known to have a higher rate of gastric ulceration than diclofenac. In Britain the Medicines and Healthcare products Regulatory Agency MHRA said in June that the drug should not be used by people with serious underlying heart conditions — people who had suffered heart failure, heart disease or a stroke were advised to stop using it completely.
A subsequent large study of 74, Danish users of NSAIDs or coxibs found no additional cardiovascular risk from diclofenac use. Diclofenac is similar in COX-2 selectivity to celecoxib. The primary mechanism responsible for its anti-inflammatory , antipyretic , and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of the transiently expressed prostaglandin-endoperoxide synthase-2 PGES-2 also known as cycloxygenase-2 COX It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis.
Research and an updated reveal of mechanism of action of diclofenac shows, that its action is as with all NSAIDs by inhibition of prostaglandin synthesis. The action of one single dose is much longer 6 to 8 h than the very short 1. This could be partly because it persists for over 11 hours in synovial fluids. Some evidence indicates it inhibits the lipoxygenase pathways, [ citation needed ] thus reducing formation of the leukotrienes also pro-inflammatory autacoids.
It also may inhibit phospholipase A2 as part of its mechanism of action. These additional actions may explain its high potency — it is the most potent NSAID on a broad basis. In practice, use of some COX-2 inhibitors with their adverse effects has led to massive numbers of patient family lawsuits alleging wrongful death by heart attack , yet other significantly COX-selective NSAIDs, such as diclofenac, have been well tolerated by most of the population.
Besides the COX-inhibition, a number of other molecular targets of diclofenac possibly contributing to its pain-relieving actions have recently been identified.
These include:. It was approved as a prescription drug and was indicated for the relief of the pain of osteoarthritis of joints responsive to topical treatment; in particular, it was prescribed for the joints in the hands, knees and feet. The name "diclofenac" derives from its chemical name: 2- 2,6- dic h lo ranilino phen yl ac etic acid. Voltaren and Voltarol contain the sodium salt of diclofenac.
In the United Kingdom, Voltarol can be supplied with either the sodium salt or the potassium salt, while Cataflam, sold in some other countries, is the potassium salt only. However, Voltarol Emulgel contains diclofenac diethylammonium, in which a 1.
On 14 January , diclofenac oral preparations were reclassified as prescription-only medicines in the UK. The topical preparations are still available without prescription. Diclofenac formulations are available worldwide under many different trade names. Use of diclofenac for animals is controversial due to toxicity when eaten by scavenging birds that eat dead animals; the medication has been banned for veterinary use in many countries.
The mechanism is presumed to be renal failure ;  however, toxicity may be due to direct inhibition of uric acid secretion in vultures. At a meeting of the National Wildlife Board in March , the Government of India announced it intended to phase out the veterinary use of diclofenac. Steppe eagles have the same vulnerability to diclofenac as vultures and may also fall victim to it. In many places, populations of feral dogs Canis familiaris have increased sharply from the disappearance of Gyps vultures as the main scavenger of wild and domestic ungulate carcasses.
Associated with the rise in dog numbers is an increased risk of rabies "  and casualties of almost 50, people. Vultures are long-lived and slow to breed.
Even if the government ban is fully implemented, it will take several years to revive the vulture population. The loss of vultures has had a social impact on the Indian Zoroastrian Parsi community, who traditionally use vultures to dispose of human corpses in Towers of Silence , but are now compelled to seek alternative methods of disposal.
Despite the vulture crisis, diclofenac remains available in other countries including many in Europe. Spain's medicine agency presented simulations suggesting that the number of deaths would be quite small. From Wikipedia, the free encyclopedia. Redirected from Diclofenac sodium. Nonsteroidal anti-inflammatory drug.
For the organic solvent sometimes called Di-clo, see Dichloromethane. For common misspellings, see Diachronic disambiguation. US DailyMed : Diclofenac. AU : C . IUPAC name. DB N. D Y. Interactive image. See also: Nonsteroidal anti-inflammatory drug. Main article: Indian vulture crisis. Retrieved 22 December Retrieved 15 February Archived from the original on 15 February Retrieved 14 February This article incorporates text from this source, which is in the public domain.
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